Disease Maps Project
The Disease Maps Project as a large-scale community effort was initiated by the Luxembourg Centre for Systems Biomedicine, the Institut Curie and the European Institute for Systems Biology and Medicine.
In order to better understand disease mechanisms, we use a direct approach and develop knowledge-based both machine- and human-readable comprehensive representations of disease mechanisms – disease maps.
A disease map is an expert-approved pathway-based reconstruction customised for a particular disease, a graphical review on the molecular mechanisms of a disease. It is a collection of interconnected signalling, metabolic and gene regulatory pathways stored in standard formats (SBGN, SBML, BioPAX).
An important part of this project is the involvement of domain experts – clinicians and biologists with extensive expertise on a topic of a particular disease. This way we ensure the quality of the developed resources.
The disease maps are to be used for omics data interpretation and identification of disease subtypes, biomarkers, corresponding molecular mechanisms and drug targets. They are to be used as the basis for different types of mathematical models and in silico experiments.
Speed-up generation of disease maps
Speed-up generation of disease maps is a new functionality we are deploying. Semi-automatic generation of disease maps involves 1) automatic merging of relevant pathway modules, 2) automatic layouting, and 3) building a collection of reusable pathway modules. This activity is done within IMI eTRIKS project.
Join the effort
We are interested in covering as many diseases as possible and invite groups that are focused on high-quality reconstruction of disease mechanisms of a particular disease or a group of diseases, or study a particular system/pathway.
Please contact us at firstname.lastname@example.org.
To participate in the Disease Maps Project discussions and to keep updated on the community effort please join the disease-maps-discuss mailing list.